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Technology

PROBLEM

Vector neutralizing antibodies block the delivery of gene therapies, limiting the number of patients that can receive them.

NabGen - The Problem with Gene Therapy

Gene therapy relies on viral vectors for delivery:

Common viruses are engineered to deliver therapeutic genes to treat specific disease(s).

Our immune system targets any foreign entity…

The human immune system naturally generates antibodies to protect against any such foreign substances.

…these antibodies (NAbs) block delivery of gene therapy

These Vector Neutralizing Antibodies (known as NAbs) significantly hamper clinical progress.

NabGen Protein

NabGen’s therapeutics transiently and safely suppress all antibodies

Key differentiators of our NG antibody suppression platform

  • Instantly blocks antibody activity
  • More effective against Nabs: 100X – 1,000X
  • Tunable duration of action: hours/days/weeks
  • Universally compatible: vector and disease agnostic
  • Delivered alone or as a formulation
  • Redosable therapeutic model
  • Optimized for clinical use and manufacturing
NabGen Protein
SOLUTION

NG: our NAb suppression platform

NabGen - Before NG NabGen - After NG